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目的 观察分析奥氮平、利培酮和喹硫平对精神分裂症患者肝功能的影响.方法 选取2014G1-2016G6期间在我院收治的96例精神分裂症患者,随机给予奥氮平、利培酮和喹硫平治疗,分为三组,每组各32例,观察比较三组患者治疗前及治疗4、8周末其谷丙转氨酶(ALT)、谷草转氨酶(AST)水平变化情况及肝功能异常例数.结果三组患者治疗4、8周末其ALT、AST水平均较治疗前明显升高,P<005,差异具有统计学意义;各组治疗后ALT、AST水平无明显差异,P>005,差异无统计学意义.利培酮组肝功能异常发生率明显高于其他两组,P<005,差异具有统计学意义.结论 奥氮平、利培酮和喹硫平对肝功能均有影响,利培酮对肝功能影响最大.
Objective To observe the effects of olanzapine, risperidone and quetiapine on the liver function of schizophrenic patients.Methods 96 cases of schizophrenia admitted to our hospital from 2014 to 2016G6 were randomly assigned to receive olanzapine, Ketones and quetiapine were divided into three groups of 32 in each group. The levels of ALT and AST in the three groups were compared before and at the 4th and 8th week of treatment, and liver function The number of abnormal cases.Results The levels of ALT and AST in the three groups at the end of the 4th and the 8th week were significantly higher than those before the treatment, P <005, the difference was statistically significant.The levels of ALT and AST in each group had no significant difference (P> 005, the difference was not statistically significant.Risperidone group, the incidence of liver dysfunction was significantly higher than the other two groups, P <005, the difference was statistically significant.Conclusion Olanzapine, risperidone and quetiapine on liver function were Affected, risperidone has the greatest impact on liver function.