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目的观察人免疫球蛋白静脉注射治疗新生儿重症肺炎临床效果。方法将2015年2月-2016年10月医院收治的新生儿重症肺炎患儿48例随机分为2组各24例。常规组给予常规治疗,免疫球蛋白组在常规组基础上给予人免疫球蛋白静脉注射治疗。观察2组治疗前后降钙素原、白细胞、C-反应蛋白、氧合指数,比较2组治疗总有效率、住院时间、感染控制时间及病死率。结果治疗前2组降钙素原、白细胞、C-反应蛋白及氧合指数比较差异无统计学意义(P>0.05);治疗后2组降钙素原、白细胞、C-反应蛋白均降低,氧合指数均升高,且免疫球蛋白组改善幅度大于常规组,差异均有统计学意义(P<0.05)。免疫球蛋白组患儿总有效率为95.83%高于常规组的75.00%,差异有统计学意义(P<0.05)。免疫球蛋白组住院时间、感染控制时间、病死率均短/低于常规组,差异均有统计学意义(P<0.05)。结论人免疫球蛋白静脉注射治疗新生儿重症肺炎临床效果确切,可有效改善患儿预后,改善临床生化指标,有效控制感染,缩短住院时间,降低病死率,值得临床推广应用。
Objective To observe the clinical effect of intravenous injection of human immunoglobulin on neonates with severe pneumonia. Methods Forty-eight neonates with severe pneumonia admitted from February 2015 to October 2016 in our hospital were randomly divided into two groups of 24 cases each. The conventional group was given routine treatment, and the immunoglobulin group was given intravenous immunoglobulin on the routine group. The levels of procalcitonin, leukocyte, C-reactive protein and oxygenation index were observed before and after treatment. The total effective rate, hospitalization time, infection control time and mortality of the two groups were compared. Results There was no significant difference in procalcitonin, leucocyte, C-reactive protein and oxygenation index between the two groups before treatment (P> 0.05). After treatment, the levels of procalcitonin, leukocyte and C-reactive protein decreased, Oxygenation index were increased, and immune globulin group improved more than the conventional group, the difference was statistically significant (P <0.05). The total effective rate of immunoglobulin group was 95.83% higher than 75.00% of the conventional group, the difference was statistically significant (P <0.05). Immunoglobulin hospital stay, infection control time, mortality were shorter / lower than the conventional group, the difference was statistically significant (P <0.05). Conclusion Intravenous immunoglobulin intravenous injection treatment of neonatal severe pneumonia clinical effect is exact, can effectively improve the prognosis of children with improved clinical biochemical indicators, effective infection control, shorter hospital stay, reduce mortality, it is worth promoting the clinical application.