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过氧化物酶体增殖剂(PPs)这类化学物质在啮齿动物中可导致过氧化物酶体增殖、肝细胞增殖,最终导致肝细胞癌,在人类则主要表现为调节脂质代谢的作用。这在过氧化物酶体增殖物激活受体α(PPARα)基因敲除鼠中被证实是通过转录因于PPARα介导的。该研究探讨PPARα在人肝组织中的表达及意义。
Peroxisome proliferator (PPs) chemicals such as these can lead to peroxisome proliferation and hepatocyte proliferation in rodents, eventually leading to hepatocellular carcinoma, and in humans, they are mainly responsible for the regulation of lipid metabolism. This is evidenced by PPARalpha-mediated transcription in peroxisome proliferator-activated receptor alpha (PPARa) knockout mice. This study was to investigate the expression of PPARα in human liver and its significance.