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目的 分析慢性肾脏病(CKD)3～5期未行肾脏替代治疗的患者血清超敏心肌肌钙蛋白Ⅰ(cTnⅠ)水平及其与肾脏相关指标的依存关系.方法 选择2016年1月～2017年11月在海南医学院第一附属医院肾内科住院的CKD3～5期未行肾脏替代治疗,且排除严重心律失常、心肌梗死以及脓毒血症的患者180例,收集血清超敏cTnⅠ并与CKD分期、肾小球滤过率(GFR)、年龄、血肌酐(Scr)、血尿素氮(BUN)、血胱抑素(CYS-C)及血白蛋白(ALB)进行统计分析.结果 多个独立样本秩和检验结果显示,超敏cTnⅠ在CKD3～5期检测水平不同,差异有统计学意义(P＜0.05).Pearson双变量相关分析显示,超敏cTnⅠ与CKD分期、GFR、CYS-C呈线性相关(P＜0.05),与Scr、BUN、ALB及年龄无线性相关关系(P＞0.05).逐步多重线性回归分析显示,超敏cTnⅠ回归方程y=-0.043+0.023X(Y:cTnI,X:CKD3～5期).结论 可根据基于CKD分期的超敏cTnⅠ回归方程校正cTnⅠ在CKD3～5期患者中的参考值,进而为临床决策提供参考.“,”Objective To analyze the level of serum hypersensitive cardiac troponin Ⅰ (cTnⅠ) in patients of chronic kidney disease (CKD) from 3 to 5 stage without renal replacement therapy.Methods A total of 180 patients of CKD from 3 to 5 stage without renal replacement therapy,severe arrhythmia,acute myocardial infarction and sepsis were selected in the First Affiliated Hospital of Hainan Medical University from January 2016 to November 2017.Then their serum hypersensitivity cTnⅠ were collected,and the correlation between the level of serum hypersensitivity cTnⅠ and glomerular filtration rate (GFR),age,serum creatinine (Scr),blood urea nitrogen (BUN),blood Cystatin-C (CYS-C) and blood albumin (ALB) were analyzed.Results The rank sum test of multiple independent samples showed that the level of serum hypersensitivity cTnⅠ in patients of CKD from 3 to 5 stage without renal replacement therapy was different,and the difference was statistically significant (P ＜ 0.05).Pearson bivariate correlation displayed hypersensitivity cTnⅠ was linearly correlated with CKD staging,GFR and CYS-C (P ＜ 0.05),and was not linearly correlated with Scr,BUN,ALB and age (P ＞ 0.05).The stepwise multiple linear regression analysis showed that the hypersensitive cTnⅠ regression equation was Y =-0.043+0.023X (Y:cTnⅠ,X:CKD3～5).Conclusion The reference value of cTnⅠ in the patients of CKD from 3 to 5 stage can be corrected according to the hypersensitive cTnⅠ regression equation,and then it can be used as a reference for clinical decision of CKD.