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本文检测了40例高血压病人,20例正常人血流动力学参数、左房内径(LAD)、左室心肌重量指数(LVMWI)和血浆心钠素(ANP)水平。结果表明,高血压病患者血浆ANP水平升高;相关分析表明,高血压病患者平均动脉压(MAP)、心尖搏动图房缩期/全舒张期比值(A/D)与血浆ANP浓度呈正相关,舒张振幅时间指数(DATI)与ANP水平呈负相关,LAD、LVMWI与ANP水平无相关性。本文结果提示高血压病患者左室舒张功能受损、MAP水平对血浆ANP水平升高有影响,血浆ANP水平升高可作为其舒张功能受损参数。
In this study, 40 patients with hypertension, 20 normal subjects hemodynamic parameters, left atrial diameter (LAD), left ventricular myocardial mass index (LVMWI) and plasma atrial natriuretic peptide (ANP) levels. The results showed that plasma ANP levels were elevated in patients with essential hypertension. Correlation analysis showed that there was a positive correlation between mean arterial pressure (MAP), atrial / systolic / diastolic ratio (A / D) and plasma ANP concentration in patients with essential hypertension , Diastolic amplitude time index (DATI) and ANP level was negatively correlated, LAD, LVMWI and ANP level no correlation. Our results suggest that left ventricular diastolic dysfunction in patients with hypertension, MAP levels of plasma ANP levels have an impact, plasma ANP levels can be used as a parameter of impaired diastolic function.