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目的初步探讨促肝细胞生长素(PHGF)联合胸腺肽α1(Tα1)治疗慢性乙型重型肝炎的临床效果。方法将104例慢性乙型重型肝炎患者随机等分成两组,对照组给予国内常用的综合基础治疗,治疗组在对照组治疗的基础上加用PHGF100mg ivgtt,pd,联合Tα11.6mg皮下注射,pod,疗程1个月,对两组治疗前后临床症状、生化指标的改善程度以及存活率进行比较。结果在临床症状、生化指标的改善程度以及存活率方面治疗组优于对照组。结论PHGF联合Tα1治疗慢性乙型重型肝炎具有较好的疗效。
Objective To investigate the clinical efficacy of hepatocyte growth-promoting factor (PHGF) combined with thymosin α1 (Tα1) in the treatment of chronic severe hepatitis B. Methods A total of 104 patients with chronic severe hepatitis B were equally divided into two groups. The control group was given the basic treatment which is commonly used in China. The treatment group was treated with PHGF100mg ivgtt, pd, subcutaneously with Tα11.6mg, pod , The course of treatment was 1 month. The clinical symptoms, the improvement of biochemical indexes and the survival rate of the two groups before and after treatment were compared. Results The clinical symptoms, the improvement of biochemical indexes and the survival rate of the treatment group were better than those of the control group. Conclusion PHGF combined Tα1 treatment of chronic severe hepatitis B has a good effect.