This paper presents an application of adaptive neural network model-based predictive control (MPC) to the air-fuel ratio of an engine simulation. A multi-layer perceptron (MLP) neural network is trained using two on-line training algorithms: a back propagation algorithm and a recursive least squares (RLS) algorithm. It is used to model parameter uncertainties in the nonlinear dynamics of internal combustion (IC) engines. Based on the adaptive model, an MPC strategy for controlling air-fuel ratio is realized, and its control performance compared with that of a traditional PI controller. A reduced Hessian method, a newly developed sequential quadratic programming (SQP) method for solving nonlinear programming (NLP) problems, is implemented to speed up nonlinear optimization in the MPC. This paper presents an application of adaptive neural network model-based predictive control (MPC) to the air-fuel ratio of an engine simulation. A multi-layer perceptron (MLP) neural network is trained using two on-line training algorithms: a back Propagation algorithm and a recursive least squares (RLS) algorithm. It is used to model parameter uncertainties in the nonlinear dynamics of internal combustion (IC) engines. Based on the adaptive model, an MPC strategy for controlling air-fuel ratio is realized, and its control performance compared with that of a traditional PI controller. A reduced Hessian method, a newly developed sequential quadratic programming (SQP) method for solving nonlinear programming (NLP) problems, implemented to speed up nonlinear optimization in the MPC.