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目的对儿童不良反应基本情况和发生特点进行分析。方法对2009-2010年大连市儿童医院上报国家药品不良反应监测网的249例ADR报告进行回顾性统计分析。结果 249例报告中男160例,女89例。1～4岁幼儿ADR比率最高。最常见的给药方式是静脉滴注、受损部位是皮肤及附件、高发期为给药后30min～1h内。抗生素和中药注射剂最易诱发ADR。结论儿童药物不良反应有其特殊性,应持续加强监测工作并及时上报。
Objective To analyze the basic situation and characteristics of children’s adverse reactions. Methods A retrospective statistical analysis of 249 cases of ADR reported by Dalian Children’s Hospital from 2009 to 2010 on the national ADR monitoring network was conducted. Results There were 160 males and 89 females in 249 cases. 1 to 4 years old children ADR the highest rate. The most common mode of administration is intravenous drip, damaged parts of the skin and accessories, high incidence period after administration of 30min ~ 1h. Antibiotics and traditional Chinese medicine injections most likely to induce ADR. Conclusion Children’s adverse drug reactions have their own particularities. Monitoring work should be continuously strengthened and timely reported.