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目的:探讨血乳酸和肌钙蛋白I变化规律在早发型重度子痫前期疾病中的价值。方法:对27例早发型重度子痫前期孕妇血乳酸和肌钙蛋白I含量进行动态监测,与同孕龄正常妊娠对照组进行比较。结果:(1)早发型重度子痫前期组血乳酸含量较同孕龄对照组有显著性差异(P<0.01);动态监测发现早发型重度子痫前期患者随子痫抽搐、引产、剖宫产手术和HELLP综合征、DIC的发生,血乳酸水平明显升高,血乳酸含量随机体损伤加重而增加;(2)动态监测发现早发型重度子痫前期1例患者,肌钙蛋白I含量随病情加重逐渐增高,入院含量为0.27ng/ml,随病情加重逐渐增高至1.4ng/ml维持数日,并出现心电图异常改变。另有2例患者入院时在(0.31～0.40 ng/ml)之间维持数日,未出现心电图异常改变。结论:动态监测血乳酸和肌钙蛋白I含量,可作为早发型重度子痫前期疾病诊疗及严重程度的监测指标和患者心肌细胞受损的理想指标。
Objective: To investigate the changes of blood lactic acid and troponin I in early-onset severe preeclampsia. Methods: The levels of serum lactate and troponin I in 27 preeclampsia patients with severe preeclampsia were dynamically monitored and compared with that of the normal gestational age pregnant control group. Results: (1) Serum lactate levels in early-onset severe preeclampsia group were significantly different from those in the same gestational age group (P <0.01). Dynamic monitoring showed that preeclampsia with seizures, induced labor, cesarean section The occurrence of operation and HELLP syndrome, the occurrence of DIC, blood lactate levels were significantly increased, blood lactate levels increased with the increase of injury; (2) Dynamic monitoring found that early onset severe preeclampsia in 1 patient, troponin I content with Increased the severity of the disease, admission was 0.27ng / ml, with the disease increased gradually increased to 1.4ng / ml for several days, and abnormal ECG changes. Another two patients were admitted to hospital between (0.31 ~ 0.40 ng / ml) for several days, no abnormal ECG changes. Conclusion: Dynamic monitoring of serum lactate and troponin I levels can be used as an indicator of diagnosis and severity of early-onset severe preeclampsia and an ideal indicator of myocardial cell damage.