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目的分析三维适形放疗与调强放疗对ⅡB期宫颈癌患者预后和生活质量的影响。方法选取2012年1月至2014年1月在我院住院治疗的60例ⅡB期宫颈癌患者作为本次研究对象,将其按照治疗方法分为3D-CRT治疗组和IMRT治疗组。放疗前、后采用RTOG/EORTC标准,对两组患者的膀胱及直肠放疗前后反应进行评价;采用FACT-CX进行生活质量评价。结果与3D-CRT治疗组比较,IMRT治疗组患者的膀胱和直肠放疗反应发生率明显更低,差异具有统计学意义(P<0.05)。治疗前两组患者生活质量各维度评分比较,差异不具有统计学意义(P>0.05);放疗治疗2年后,两组患者生活质量各维度评分均升高,IMRT治疗组生活质量各维度评分较3D-CRT治疗组更高,差异有统计学意义(P<0.05)。结论 IMRT治疗可明显减少ⅡB期宫颈癌患者的放疗反应,对提高患者的生活质量有重要意义。
Objective To analyze the effect of three-dimensional conformal radiotherapy (IMRT) and intensity-modulated radiotherapy (IMRT) on prognosis and quality of life in patients with stage ⅡB cervical cancer. Methods Sixty patients with stage ⅡB cervical cancer who were hospitalized in our hospital from January 2012 to January 2014 were selected as the study subjects and divided into 3D-CRT group and IMRT group according to the method of treatment. The RTOG / EORTC criteria were used before and after radiotherapy to evaluate the response of bladder and rectum before and after radiotherapy. The quality of life was evaluated by FACT-CX. Results Compared with the 3D-CRT group, the incidence of bladder and rectal radiotherapy in the IMRT group was significantly lower, with statistical significance (P <0.05). The scores of quality of life in the two groups before treatment were not significantly different (P> 0.05). After 2 years of radiotherapy, the scores of quality of life in both groups were increased, and the scores of quality of life in IMRT group Compared with 3D-CRT group, the difference was statistically significant (P <0.05). Conclusion IMRT treatment can significantly reduce the radiotherapy response of patients with stage Ⅱ B cervical cancer, which is of great significance to improve the quality of life of patients.