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目的利用核素显像法观察放疗对鼻咽癌患者腮腺功能的影响。方法常规根治放疗患者4例分别于放疗前、放疗疗程结束第1天、放疗后3个月行99mTcO4-腮腺动态显像;6例常规放疗及11例适形调强放疗的鼻咽癌患者于放疗前、放疗后显像,结合影像学表现和半定量指标Ex值对腮腺功能进行判断。结果4例行常规放疗的患者放疗后腮腺功能明显下降(P<0．05);放疗结束第1天与3个月腮腺功能无显著性差异(P>0．05);常规放疗与适形调强放疗后Ex值下降平均数分别为41．10％和21．11％(P<0．01),两组均未出现极度损伤。结论鼻咽癌患者常规根治放疗后其腮腺功能受损,3个月后未见明显恢复;适形调强放疗法较常规放疗法对腮腺的损伤较小;腮腺动态显像是一种合适的监测方法。
Objective To observe the effect of radiotherapy on parotid gland function in patients with nasopharyngeal carcinoma by radionuclide imaging. Methods Four patients with conventional radical radiotherapy were given 99mTcO4-parotid gland dynamic imaging before radiotherapy, one day after the end of radiotherapy, and three months after radiotherapy. Six patients with nasopharyngeal carcinoma underwent routine radiotherapy and conformal IMRT Radiotherapy, radiotherapy after imaging, combined with imaging findings and semi-quantitative index Ex value of the parotid function to judge. Results The function of parotid gland in 4 patients with conventional radiotherapy was significantly decreased after radiotherapy (P <0.05). There was no significant difference in parotid function between the first day and the third month after radiotherapy (P> 0.05). Conventional radiotherapy and conformal radiotherapy The average value of Ex-value after intensity-modulated radiotherapy was 41.10% and 21.11% respectively (P <0.01), and no extreme damage occurred in both groups. Conclusions Nasopharyngeal carcinoma patients have impaired parotid gland function after conventional radical radiotherapy and no significant recovery after 3 months. Contralateral intensity modulated radiation therapy has less damage to the parotid gland than conventional radiotherapy. Parotid dynamic imaging is a suitable Monitoring method.