目的:分析子宫肌瘤采用小剂量米非司酮治疗的临床治疗效果。方法:选取我院2003年1月~2013年12月期间收治的100例子宫肌瘤患者,按每组50例患者随机分为A、B两组。给予A组患者12.5mg/d米非司酮治疗,给予B组患者25mg/d米非司酮治疗,对比两组患者临床治疗效果。结果:A、B两组患者子宫体积、子宫肌瘤体积以及血红蛋白等比之治疗前均有明显改善,差异显著具有统计学意义(P<0.05)。A、B两组患者治疗后对比,差异无统计学意义(P>0.05)。A组患者不良反应发生率为1.0%,B组患者不良反应发生率为5.0%。两组患者不良反应发生率对比,差异显著具有统计学意义(P<0.05)。结论:小剂量米非司酮治疗子宫肌瘤效果显著,患者不良反应发生率更低,安全性高,具有临床推广价值。 Objective: To analyze the clinical effect of low dose mifepristone treatment in uterine fibroids. Methods: A total of 100 patients with uterine fibroids who were treated in our hospital from January 2003 to December 2013 were randomly divided into A and B groups, 50 patients in each group. Patients in group A received 12.5 mg / day mifepristone, and patients in group B received 25 mg / day mifepristone. The clinical effects were compared between the two groups. Results: The volume of uterus, the volume of uterine fibroids and the ratio of hemoglobin in group A and B were significantly improved before treatment, the difference was statistically significant (P <0.05). There was no significant difference between A and B groups after treatment (P> 0.05). A group of patients with adverse reactions was 1.0%, B patients with adverse reactions was 5.0%. Adverse reactions between the two groups were compared, the difference was statistically significant (P <0.05). Conclusion: The low dose of mifepristone treatment of uterine fibroids significant effect, patients with lower incidence of adverse reactions, high safety, with clinical value.