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目的:观察独活寄生汤联合甲氨蝶呤、柳氮磺吡啶治疗强直性脊柱炎的临床疗效。方法:将87例强直性脊柱炎患者随机分成对照组45例和治疗组42例。对照组予甲氨蝶呤片联合柳氮磺吡啶片治疗,治疗组在对照组西药治疗基础上加用独活寄生汤加减治疗。结果:治疗3个月后,总有效率治疗组为85.71%,对照组为46.67%,组间比较,差异有统计学意义(P<0.05);两组中医证候积分、BASDAI、BASFI、脊柱痛(VAS评分)、指地距及实验室指标hs-CRP、ESR治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P<0.05)。结论:独活寄生汤联合甲氨蝶呤、柳氮磺吡啶治疗强直性脊柱炎疗效确切。
OBJECTIVE: To observe the clinical efficacy of “Duhuo FuSheng Decoction” combined with methotrexate and sulfasalazine in the treatment of ankylosing spondylitis. Methods: 87 patients with ankylosing spondylitis were randomly divided into control group (n = 45) and treatment group (n = 42). The control group was treated with methotrexate tablets combined with sulfasalazine tablets, and the treatment group was treated with the addition of “Doxue parasitic soup” on the basis of western medicine in the control group. Results: After three months of treatment, the total effective rate was 85.71% in the treatment group and 46.67% in the control group, with significant difference between the two groups (P <0.05). The scores of TCM syndromes, BASDAI, BASFI, Pain (VAS score), mean distance and laboratory hs-CRP, ESR before and after treatment group comparison and after treatment, the differences were statistically significant (P <0.05). Conclusion: Doxue parasitic soup combined with methotrexate, sulfasalazine treatment of ankylosing spondylitis exact effect.