论文部分内容阅读
他汀类药物具有肯定的降血脂作用,已作为冠状动脉粥样硬化性心脏病的二级预防用药。大量研究显示,他汀类药物除降脂作用外,还有多效的非调脂作用如抗炎作用、改善内皮功能、改善心室重塑、恢复心脏自主神经功能、抗氧化作用。近年来很多研究表明,他汀类药物的多效性对慢性心力衰竭的治疗有益,可延缓慢性心力衰竭进展,改善心功能,降低慢性心力衰竭病死率、致残率。但同时也有一些潜在的不利影响,他汀类药物能否常规用于慢性心力衰竭的治疗还有待循证医学证实。
Statins have a positive hypolipidemic effect and have been used as secondary prophylaxis for coronary atherosclerotic heart disease. Numerous studies have shown that in addition to lipid-lowering effect of statins, there are multiple non-lipid-lowering effects such as anti-inflammatory effect, improve endothelial function, improve ventricular remodeling, restore cardiac autonomic nervous function, anti-oxidation. In recent years, many studies have shown that the pleiotropic effect of statins is beneficial to the treatment of chronic heart failure, which can delay the progression of chronic heart failure, improve cardiac function and reduce the mortality and morbidity of chronic heart failure. However, there are also some potential adverse effects. The routine use of statins for the treatment of chronic heart failure remains to be confirmed by evidence-based medicine.