随着药物化学的进展,苯并含氮或含硫的七员杂环化合物受到越来越多的关注。这类化合物具有一定的生理活性,它们的立体化学及反应过程都是很有意思的。我们通过图1所示方法合成了一系列四氢2,4-二取代-1,5-苯并二氮杂(艹卓)类化合物。合成的最后一步反应使用NaBH_4还原,可能生成顺式和反式两种异构体(图2)。测定不同化合物顺式和反式异构体的相对含量,从而了解不同取代基对产物立体化学的 With the development of medicinal chemistry, more attention has been paid to the nitrogen-containing or sulfur-containing seven-membered heterocyclic compounds. These compounds have some physiological activity, their stereochemistry and the reaction process are very interesting. We have synthesized a series of tetrahydro-2,4-disubstituted-1,5-benzodiazepines by the method shown in Fig.1. The final step of the reaction, using NaBH4 reduction, may generate both the cis and trans isomers (Figure 2). Determination of different compounds cis and trans isomers relative content, so as to understand the different substituents on the product stereochemistry