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目的 研究CD44V6、VEGF蛋白在正常胃粘膜、癌前病变以及胃癌的表达和它们与胃癌临床病理关系。方法 应用免疫组化S—P法对三种胃组织标本CD44V6及VEGF的表达情况进行观察。结果 正常胃粘膜无CD44V6、VEGF表达。癌前病变CD44V6、VEGF阳性表达率分别为 9.4%、12 .5 %。胃癌的阳性表达率为 6 4.7%和 5 8.5 % ,随浸润深度加深 ,淋巴结或远处转移、TNM分期上升、CD44V6、VEGF而升高。结论 CD44V 6、VEGF的表达随胃癌的进展而升高 ,据此可作为判定胃癌恶性程度的指标 ;与浸润深度、淋巴结及远处转移、TNM分期呈正相关 ,检测CD44V6、VEGF可作为胃癌生物学进展的指标
Objective To study the expression of CD44V6 and VEGF protein in normal gastric mucosa, precancerous lesions and gastric carcinoma and their relationship with clinicopathological features of gastric cancer. Methods The expression of CD44V6 and VEGF in three kinds of gastric tissues were observed by immunohistochemical S-P method. Results There was no CD44V6 and VEGF expression in normal gastric mucosa. The positive rates of CD44V6 and VEGF in precancerous lesions were 9.4% and 12.5%, respectively. The positive rate of gastric cancer was 6.7% and 8.5%, respectively. The depth of invasion, lymph node or distant metastasis, TNM staging, CD44V6, VEGF increased. Conclusions The expression of CD44V6 and VEGF is up-regulated with the progress of gastric cancer, which can be used as an index to determine the degree of malignancy of gastric cancer. It is positively correlated with the depth of invasion, lymph node and distant metastasis, and TNM stage. CD44V6 and VEGF can be used as a marker for gastric cancer biology Indicators of progress