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目的:研究TGF-β1在子宫腺肌病(adenomysis,AM)不同部位的表达水平以及子宫腺肌病部位与痛经的关系,探讨子宫腺肌病患者痛经的病因。方法:运用免疫组化法从蛋白水平检测子宫腺肌病及子宫肌瘤在位内膜及病灶TGF-β1的表达水平,分析其与痛经的关系。结果:①子宫腺肌病组在位内膜及异位内膜中TGF-β1的表达水平高于对照组,差异有统计学意义(P<0.05);②子宫腺肌病不同部位与痛经强度差异有统计学意义(P<0.05);③不同部位子宫腺肌病患者的TGF-β1表达差异无统计学意义(P>0.05);④不同痛经强度的子宫腺肌病患者TGF-β1表达差异无统计学意义(P>0.05)。结论:子宫腺肌病TGF-β1的表达水平增高与痛经有一定的关系;子宫腺肌病部位与痛经密切相关,而与病灶大小无关;推测盆腔中不同部位的神经丛分布与TGF-β1的神经调节共同参与了痛经的发生。
OBJECTIVE: To investigate the expression of TGF-β1 in different parts of adenomyosis (AM) and the relationship between adenomyosis and dysmenorrhea, and to explore the etiology of dysmenorrhea in patients with adenomyosis. Methods: Immunohistochemistry was used to detect the expression of TGF-β1 in the eutopic and focal ectopia of uterine adenomyosis and uterine leiomyoma from the protein level, and its relationship with dysmenorrhea was analyzed. Results: ① The expression of TGF-β1 in eutopic and ectopic endometrium of adenomyosis group was higher than that of control group (P <0.05); ②The different parts of adenomyosis and dysmenorrhea intensity (P <0.05); ③ The expression of TGF-β1 in different parts of adenomyosis had no significant difference (P> 0.05); ④The expression of TGF-β1 in patients with different dysmenorrhea intensity No statistical significance (P> 0.05). CONCLUSIONS: The increased expression of TGF-β1 in adenomyosis has a certain relationship with dysmenorrhea. The location of adenomyosis is closely related to dysmenorrhea but not to the size of the lesion. It is speculated that the distribution of plexus in different parts of the pelvis is similar to that of TGF-β1 Neuromodulation involved in the occurrence of dysmenorrhea.