目的对比分析帕金森病痴呆经认知功能康复训练与盐酸多奈哌齐治疗的临床效果。方法数字随机法抽取2015年3月-2017年3月期间该院接收并治疗的帕金森痴呆患者74例并分为两组,对照组采用盐酸多奈哌齐治疗,试验组则采用认知功能康复训练与盐酸多奈哌齐治疗,比较两组治疗以后的临床疗效。结果试验组治疗以后UPDRS、Barthel指数、MoCA评分均优于对照组,组间对比差异有统计学意义(P<0.05);且试验组总有效率94.59%,高于对照组的78.38%,组间对比差异有统计学意义(P<0.05)。结论帕金森病痴呆经认知功能康复训练与盐酸多奈哌齐治疗的临床效果显著,可推广。 Objective To compare the clinical effects of cognitive rehabilitation training and donepezil hydrochloride in treating Parkinson’s disease dementia. Methods 74 patients with Parkinson’s dementia received and treated in our hospital from March 2015 to March 2017 were randomly divided into two groups. The control group was treated with donepezil hydrochloride, and the experimental group received cognitive rehabilitation training and Donepezil hydrochloride treatment, the clinical efficacy of the two groups after treatment compared. Results The UPDRS, Barthel index and MoCA score of the experimental group were better than those of the control group after treatment, and the difference between the two groups was statistically significant (P <0.05). The total effective rate was 94.59% in the experimental group, 78.38% higher than that in the control group The difference between the two groups was statistically significant (P <0.05). Conclusion The clinical effect of cognitive rehabilitation training and donepezil hydrochloride in treating Parkinson’s disease dementia is significant and can be promoted.