论文部分内容阅读
肾脏间质纤维化促进肾脏功能恶化,其程度是预测肾脏病情的重要指标。其机制十分复杂,目前认为TGF-β1/Smad信号通路介导的小管上皮细胞向间充质细胞转分化起主要作用。本文就这一方面的进展作一综述。
Renal interstitial fibrosis promotes deterioration of renal function, and its extent is an important indicator of renal disease. The mechanism is very complex, now that the TGF-β1 / Smad signaling pathway of tubular epithelial cells to mesenchymal cells transdifferentiation play a major role. This article reviews the progress in this area.