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目的:观察益肾通络方对大鼠的急性毒理作用。方法:将40只SD大鼠随机分为受试组和对照组,每组20只,受试组大鼠以益肾通络方汤剂最大浓度灌胃给药,空白对照组灌服相同体积的蒸馏水,连续14d;观察大鼠死亡数及益肾通络方对大鼠的体质量和脏器的影响。结果:大鼠无死亡现象,益肾通络方对肝、脾、肾、胃、肠、心、肺等主要脏器无明显影响;未测出LD50;其最大给药量为150g/kg体质量,相当于临床剂量的64倍,未出现异常的毒性反应。结论:益肾通络方具有较高的安全性。
Objective: To observe the acute toxicity of Yishen Tongluo Prescription to rats. Methods: Forty SD rats were randomly divided into test group and control group, with 20 rats in each group. The rats in the test group were intragastrically administered with the maximum concentration of Yishen Tongluo Decoction, and the blank control group was given the same volume Of distilled water, continuous 14d; observed the number of rats died and Yishentongluo on body weight and organs of rats. Results: There was no death in rats. Yishen Tongluo Formula had no significant effect on the major organs such as liver, spleen, kidney, stomach, intestine, heart and lung. LD50 was not detected. The maximum dosage was 150g / kg body Quality, equivalent to 64 times the clinical dose, did not appear abnormal toxicity. Conclusion: Yishen Tongluo prescription has higher safety.