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目的探讨急性乙醇中毒合并敌敌畏中毒时,血浆中乙醇浓度与血浆中敌敌畏含量及患者预后的相关性。方法将74例敌敌畏中毒患者分为单纯中毒组与混合中毒组,所有患者均检测其入院时血浆中胆碱酯酶、敌敌畏浓度,对合并乙醇中毒者检测血浆中乙醇浓度,对两组患者的性别、年龄、敌敌畏浓度、胆碱酯酶活力和死亡率进行统计学分析,并对乙醇浓度与敌敌畏浓度及胆碱酯酶活力进行相关分析。结果与对照组相比,混合中毒组男性患者明显高于女性,其血浆中敌敌畏浓度、患者病死率明显升高,胆碱酯酶活力降低显著;血浆中乙醇浓度与血浆中敌敌畏浓度呈正相关,而与胆碱酯酶活力呈负相关;结论急性乙醇中毒合并敌敌畏中毒时,血浆敌敌畏浓度明显升高,病死率明显增加。
Objective To investigate the correlation between the concentration of ethanol in plasma and the concentration of dichlorvos in plasma and the prognosis of patients with acute ethanol poisoning complicated with dichlorvos poisoning. Methods 74 cases of patients with dichlorvos poisoning were divided into simple poisoning group and mixed poisoning group, all patients were tested on admission to the plasma concentrations of cholinesterase, dichlorvos, ethanol poisoning were detected in plasma concentrations of ethanol, the two groups of patients Gender, age, concentration of dichlorvos, cholinesterase activity and mortality were statistically analyzed. The correlations between ethanol concentration and concentration of dichlorvos and cholinesterase activity were analyzed. Results Compared with the control group, the male patients in the mixed poisoning group were significantly higher than those in the female group. The plasma concentration of dichlorvos and the patients’ mortality were significantly increased, while the cholinesterase activity was significantly decreased. The concentration of ethanol in plasma was positively correlated with the concentration of dichlorvos in plasma, But negatively correlated with the activity of cholinesterase. Conclusions When the concentration of dichlorvos in acute alcoholism combined with dichlorvos poisoning is significantly increased, the case fatality rate obviously increases.