论文部分内容阅读
目的探讨和总结F0LFOX4与FOLFOX6两种化疗方案治疗晚期胃癌的比较。方法将我院2005年3月至2009年6月收治的80例晚期胃癌随机分成两组,F0LFOX4治疗组和FOLFOX6治疗组各40例,观察两组的临床疗效及不良反应。结果 F0LFOX4治疗组CR5例,PR10例,SD17例,PD8例,总有效率37.5%;临床获益30例(80%);主要出现骨髓毒性和消化道反应等不良反应;FOL-FOX6治疗组CR8例,PR15例,SD13例,PD4例,总有效率57.5%;临床获益36例(90%),主要表现为骨髓毒性和消化道反应等不良反应。结论 F0LFOX4与FOLFOX6两种化疗方案的毒副反应均较轻,疗效较高,耐受性较好,安全可靠,FOLFOX6比F0LFOX4简便易行,现多采用FOLFOX6治疗晚期胃癌,通过积极、有效的治疗,提高患者生存率。
Objective To investigate and summarize the comparison of two chemotherapy regimens, F0LFOX4 and FOLFOX6, for the treatment of advanced gastric cancer. Methods 80 cases of advanced gastric cancer admitted to our hospital from March 2005 to June 2009 were randomly divided into two groups. F0LFOX4 treatment group and FOLFOX6 treatment group were 40 cases. The clinical efficacy and adverse reactions were observed. Results F0LFOX4 treatment group CR5 cases, PR10 cases, SD17 cases, PD8 cases, the total effective rate of 37.5%; clinical benefit of 30 cases (80%); mainly bone marrow toxicity and gastrointestinal reactions and other adverse reactions; FOL-FOX6 treatment group CR8 Cases, PR15 cases, SD13 cases, PD4 cases, the total effective rate of 57.5%; Clinical benefit 36 cases (90%), mainly for bone marrow toxicity and gastrointestinal reactions and other adverse reactions. Conclusions Both F0LFOX4 and FOLFOX6 have less side effects, higher efficacy, better tolerability and safety. FOLFOX6 is easier and more convenient than F0LFOX4. FOLFOX6 is often used to treat advanced gastric cancer, and active and effective treatment is used. , improve patient survival.