目的：研究了卡铂白蛋白微球经肝动脉栓塞后的体内动力学过程、组织分布情况及微球在肝脏动脉栓塞的效果，观察对正常肝脏的病理改变。方法：栓塞实验以肝动脉灌注卡铂注射剂为对照组。用石墨炉原子吸收分光光度法检测外周静脉血及组织中的药物浓度。结果：卡铂注射剂和微球剂的体内过程呈二室模型，微球剂分布相半衰期（Ｔ１／２α）和消除相半衰期（Ｔ１／２β）分别为１．３ｈ和３２．２ｈ，均明显长于注射剂（Ｔ１／２α和Ｔ１／２β分别为１．１ｈ和１６．１ｈ）。肝脏中的药物浓度远远高于脾、心、肺等组织中的药物浓度，注射后６ｄ亦高于其蓄积器官肾脏的药物浓度。电子显微镜下肝脏病理切片可见微球栓塞在肝动脉末端。栓塞作用于灌注３周后仍存在 OBJECTIVE: To study the in vivo kinetics, tissue distribution and microspheres embolization of hepatic artery in carboplatin albumin microspheres after hepatic artery embolization. The pathological changes in normal liver were observed. Methods: Embolization experiment with hepatic artery infusion carboplatin injection as control group. Graphite Furnace Atomic Absorption Spectrophotometry for the Detection of Drug Concentrations in Peripheral Venous Blood and Tissues. Results: The in vivo process of carboplatin injection and microsphere was a two-compartment model. The distribution half-life (T1 / 2α) and elimination half-life (T1 / 2β) of microspheres were 1.3h and 32.2h, Injections (T1 / 2α and T1 / 2β 1.1h and 16.1h, respectively). The drug concentration in the liver is much higher than that in the spleen, heart, lung and other tissues. After 6 days of injection, the drug concentration in the liver is also higher than that in the kidney of the accumulating organ. Electron microscopic liver pathology shows microspheres embolization in the hepatic artery. Embolization still exists after 3 weeks of perfusion