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目的:研究高敏肾移植受者术前行单次免疫吸附治疗对群体反应性抗体(PRA)水平影响。方法:对24例高敏受者应用葡萄球菌蛋白A(SPA)单次吸附治疗1次,进行临床移植观察。结果:免疫吸附治疗后24 h查PRA,转阴率91.6%,有效率100%。行肾移植术,排斥反应发生率为12.5%,1 a移植肾存活率91.6%,2 a移植肾存活率87.5%。结论:采用SPA可降低高敏受者体内预存抗体水平,并辅以新型免疫抑制剂,对预防和减少肾移植术后排斥反应疗效肯定。
OBJECTIVE: To study the effect of single immunosorbent on the level of PRA in patients with high-sensitivity nephropathy. Methods: Twenty-four patients with hypersensitivity recipients were treated with single-staphylococcal protein A (SPA) for 1 time, and then were transplanted for clinical observation. Results: PRA was detected 24 h after immunosuppression, with a negative conversion rate of 91.6% and an effective rate of 100%. Renal transplantation, the incidence of rejection was 12.5%, 1 a graft survival rate of 91.6%, 2 a graft survival rate of 87.5%. Conclusion: SPA can reduce the level of pre-existing antibodies in hypersensitive recipients, supplemented with new immunosuppressive agents, to prevent and reduce the rejection after renal transplantation.