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目的探讨经间期出血患者的发病机制。方法将70例经间期出血患者(观察组)与35例月经正常者(正常组)进行对照,监测2组月经不同时期的子宫内膜厚度、内分泌指标和凝血指标。结果观察组在月经7～10d子宫内膜显著增厚,而21～25d显著变薄。在月经1～3d血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、孕酮(P0)水平显著升高;7～10dLH显著升高,E2显著下降;21～25dE2、P0均显著下降。凝血指标无明显变化。结论排卵前期低水平的雌激素不足以支持此期相对增厚的子宫内膜而出现少量的突破性出血,与凝血机制无明显关联。
Objective To investigate the pathogenesis of patients with inter-menstrual bleeding. Methods Seventy patients with interphase hemorrhage (observation group) and 35 normal subjects (normal group) were enrolled in this study. The endometrial thickness, endocrine index and coagulation index were measured in two groups at different stages of menstruation. Results In the observation group, the endometrium was significantly thicker at 7 to 10 days of menstruation, and thinned significantly at 21 to 25 days. The levels of serum FSH, LH, E2 and P0 were significantly increased from 1 to 3 days after menstruation; the levels of FSH, E2 and E2 were significantly increased from 7 to 10 days; 25dE2, P0 were significantly decreased. No significant changes in coagulation index. Conclusion The low level of estrogen in early stage of ovulation is not enough to support the relative thickening of the endometrium in this period and a small amount of breakthrough bleeding, no significant correlation with the coagulation mechanism.