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目的比较不同价态铬化合物急性毒性及致突变毒性。方法采用鼠伤寒沙门菌/微粒体试验(Ames)实验、小鼠急性毒性实验和小鼠骨髓微核实验检测铬化合物的急性毒性和致突变毒性。结果 K2Cr2O7的LD50明显高于CrCl3;Ames试验CrCl3呈阴性结果,K2Cr2O7呈阳性结果。小鼠骨髓微核实验CrCl3呈阴性结果;K2Cr2O7各剂量组微核率明显高于对照组(P<0.05),CrCl3和K2Cr2O7各剂量组骨髓细胞PCE/RBC比值随剂量的增高均呈现下降趋势,但均高于0.1。结论本实验表明CrCl3不具有致突变作用,K2Cr2O7不但急性毒性明显高于CrCl3,而且具有致突变作用。
Objective To compare acute toxicity and mutagenic toxicity of different valence chromium compounds. Methods Acute toxicity and mutagenic toxicity of chromium compounds were detected by Salmonella typhimurium / microsome test (Ames), acute toxicity test in mice and micronucleus test in mouse bone marrow. Results The LD50 of K2Cr2O7 was significantly higher than that of CrCl3. The results of Ames test were negative for CrCl3 and positive for K2Cr2O7. (P <0.05). The ratios of PCE / RBC in bone marrow cells of all doses of CrCl3 and K2Cr2O7 showed a decreasing trend with the increase of the dosage. The micronucleus rate of each dose of K2Cr2O7 was significantly higher than that of the control group But higher than 0.1. Conclusion This experiment shows that CrCl3 does not have mutagenic effect. K2Cr2O7 not only has higher acute toxicity than CrCl3 but also has mutagenic effect.