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甲氟喹虽能有效地治疗抗氯喹和对氯喹敏感的急性恶性疟病人,但单独使用时很容易产生抗性。法西达(周效磺胺与乙氨嘧啶之比为20:1)虽可有效地扑灭疟疾,但在巴西、泰国和非洲已报告该药可增加恶性疟对周效磺胺/乙氨嘧啶的抗性。本文报道了抗疟新药Fansimef(甲氟喹、周效磺胺和乙胺嘧啶合剂)治疗恶性疟现症病人的双盲试验结果。Fansimef每片含甲氟喹250mg、周效磺胺500mg和乙氨嘧啶25mg。实验采用双
Although mefloquine is effective in the treatment of chloroquine and chloroquine-sensitive acute falciparum malaria, it is easily tolerated when used alone. Although fesidacyc (potent sulfonamides and pyrimethamine ratio of 20: 1) effectively eradicated malaria, it has been reported in Brazil, Thailand and Africa to increase the resistance of P. falciparum to pSa / pyrimidine Sex. This article reports the results of a double-blind trial of the antimalarial drug Fansimef (mefloquine, pessary and pyrimethamine) in the treatment of patients with falciparum malaria. Fansimef each containing mefloquine 250mg, sulfasalazine 500mg and 25mg of pyrimethamine. Experiment with double