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自从1948年Rickes及Smith二氏在肝制剂中分离出维生素B_(12)(以下简称B_(12))后,近年来在临床上应用渐广,现就手边有关材料综述如下。一般药理特性B_(12)是活力最强的维生素,分子式为C_(16-64)H_(86-92)N_(14)PCo,但正确结构目前尚不清楚。为已发现维生素中的唯一含有金属者,由于含钴,故呈红色结晶。易溶于水,在中性溶液中很稳定,在酸、鹼性溶液中以及遇强氧化剂或还原剂,则均易被破坏。水溶液一般在100℃时可维持30分钟,120℃时可维持15分钟不被破坏。
Since the separation of vitamin B 12 (hereinafter referred to as B 12) from liver preparations by Rickes and Smith in 1948, there has been a wide range of clinical applications in recent years. General Pharmacological Characteristics B 12 is the most active vitamin with the molecular formula C 16-64 H 86-92 N 14 PCo, but the exact structure is not yet clear. It is the only metal-containing vitamin found in humans that is red in color as it contains cobalt. Soluble in water, very stable in neutral solution, in acid, alkaline solution and in case of strong oxidant or reductant, are easily damaged. The aqueous solution is generally maintained at 100 ° C for 30 minutes, 120 ° C for 15 minutes without damage.