A Practical Synthesis of (S)-(+)-2-(6(-methoxyl-2-naphthyl) propionic Acid

来源 :中国化学快报 | 被引量 : 0次 | 上传用户：ip81890

【摘要】

：

A simplified procedure for enantioselective synthesis of (S)-(+)-2-(6(-methoxyl-2- naphthyl) propionic acid ((S)-(+)-naproxen), starting from (6-methoxy-(-napht

【作者】

：

Hong Zhu MA Bo WANG Qi Zhen SH

【机构】

：

Department of Chemistry

【出处】

：

中国化学快报

【发表日期】

：

2004年期

【关键词】

：

Auxiliary D-mannitol enantioselective synthesis one-pot (S)-(+)-naproxen

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A simplified procedure for enantioselective synthesis of (S)-(+)-2-(6(-methoxyl-2- naphthyl) propionic acid ((S)-(+)-naproxen), starting from (6-methoxy-(-naphthyl) -1-propanone, with D-mannitol as auxiliary catalyzed by SmCl3 in one-pot is described. The yield is 87.5 %(ee value 99 %).

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A Practical Synthesis of (S)-(+)-2-(6(-methoxyl-2-naphthyl) propionic Acid

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