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目的探讨MMP2和TIMP2的表达与膀胱移行细胞癌(BTCC)发生、发展的关系,评价它们判断BTCC术后复发的临床价值。方法收集1998年1月至2000年12月我院BTCC石蜡包埋固定手术标本36例,正常膀胱黏膜10例作为对照,应用流式细胞术检测BTCC及正常膀胱黏膜组织中的MMP2和TIMP2的含量。随访BTCC患者复发情况。结果BTCC组织中MMP2的表达高于对照组;MMP2在浅表性膀胱癌中的表达明显低于浸润性膀胱癌,MMP2在复发组的表达明显高于非复发组中的表达。TIMP2与之相反。结论MMP2和TIMP2的异常表达与BTCC发生、发展密切相关,MMP2和TIMP2有望作为提示BTCC复发的标记物。
Objective To investigate the relationship between the expression of MMP2 and TIMP2 and the occurrence and development of bladder transitional cell carcinoma (BTCC), and to evaluate the clinical value of MMP2 and TIMP2 in determining the recurrence of BTCC. Methods From January 1998 to December 2000, 36 cases of BTCC embedded in paraffin-embedded surgical specimens and 10 cases of normal bladder mucosa were collected as control. The contents of MMP2 and TIMP2 in BTCC and normal bladder mucosa were detected by flow cytometry . Follow-up of patients with BTCC recurrence. Results The expression of MMP2 in BTCC was higher than that in control group. The expression of MMP2 in superficial bladder cancer was significantly lower than that in invasive bladder cancer. The expression of MMP2 in recurrence group was significantly higher than that in non-recurrence group. In contrast, TIMP2. Conclusion The abnormal expression of MMP2 and TIMP2 is closely related to the occurrence and development of BTCC. MMP2 and TIMP2 are expected to be the markers of BTCC recurrence.