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目的:考察注射用阿莫西林钠舒巴坦钠[4:1,AMCL-SBT(4:1)]、注射用阿莫西林钠舒巴坦钠[2:1,AMCL-SBT(2:1)]的体内抗菌作用,比较2种受试物的半数有效量(ED_(50))。方法:分别以金黄色葡萄球菌(S.aureus)、肺炎克雷伯菌(K.pneumoniae)、大肠杆菌(E.coli)作为感染菌对小鼠进行腹腔注射,对已感染的小鼠按不同组别分别静脉注射AMCL-SBT(4:1)和AMCL-SBT(2:1)各剂量,计算ED_(50)值。结果:AMCL-SBT(4:1)和AMCL-SBT(2:1)对S.aureus感染小鼠的ED_(50)分别为293.7和292.5 mg·kg~(-1),对K.pneumoniae感染小鼠的ED_(50)分别为293.1和271.0 mg·kg~(-1),对E.coli感染小鼠的ED_(50)分别为240.4和231.9 mg·kg~(-1)。其ED_(50)值经t检验比较,差别均无统计学意义(P>0.05)。结论:AMCL-SBT(4:1)和AMCL-SBT(2:1)对S.aureus、K、pneumoniae、E.coli感染的小鼠均有较好的保护作用,且体内的抗菌作用相当。
Objective: To investigate the effects of amoxicillin and sulbactam sodium [4: 1, AMCL-SBT (4: 1)] for injection on amoxicillin and sulbactam sodium [2: 1, AMCL-SBT )] In vivo antibacterial activity, compared two kinds of test substance half effective amount (ED_ (50)). Methods: The mice were injected intraperitoneally with S. aureus, K. pneumoniae and E. coli as infected cells respectively, The rats in each group were given intravenous AMCL-SBT (4: 1) and AMCL-SBT (2: 1) doses, respectively. Results: ED50 of AMCL-SBT (4: 1) and AMCL-SBT (2: 1) in S.aureus infected mice were 293.7 and 292.5 mg · kg -1, respectively, The ED 50 of mice was 293.1 and 271.0 mg · kg -1, respectively. The ED 50 of mice infected with E. coli were 240.4 and 231.9 mg · kg -1, respectively. The ED 50 value of t test showed no significant difference (P> 0.05). CONCLUSION: AMCL-SBT (4: 1) and AMCL-SBT (2: 1) have a good protective effect against S.aureus, K, pneumoniae and E.coli infected mice, and their antibacterial activity is similar in vivo.