论文部分内容阅读
目的对T2DM患者予以胰岛素联合艾塞那肽的治疗,观察艾塞那肽对T2DM的疗效。方法将入选的60例T2DM患者随机分为A组和B组,各30例。A组使用预混胰岛素治疗,B组在A组方案基础上加用艾塞那肽治疗,随访4个月,比较两组患者血糖控制、胰岛β细胞功能以及血脂、体重等变化情况。结果两组患者血糖均得到良好控制,B组△2hPG低于A组(P<0.05),△2hC-P、△HOMA-β则高于A组(P<0.05)。另外,B组患者BMI、TG较治疗前明显下降。结论使用艾塞那肽可改善T2DM患者的血糖和胰岛β细胞功能,减少胰岛素使用剂量,降低体重。
Objective To investigate the effect of exenatide on T2DM in patients with T2DM treated with insulin combined with exenatide. Methods Sixty patients with T2DM were randomly divided into group A and group B, with 30 cases in each. Group A was treated with premixed insulin. Group B was treated with exenatide on the basis of group A for 4 months. Blood glucose, islet β-cell function, blood lipid and body weight were compared between the two groups. Results The blood glucose in both groups was well controlled. The △ 2hPG in group B was lower than that in group A (P <0.05), but △ 2hC-P and △ HOMA-β were higher than those in group A (P <0.05). In addition, B group patients with BMI, TG decreased significantly before treatment. Conclusion Exenatide can improve blood glucose and pancreatic β-cell function in T2DM patients, reduce the dose of insulin and reduce body weight.