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目的:观察复方番石榴制剂对2型糖尿病合并代谢综合征患者胰岛β细胞功能的影响。方法:采用随机对照临床试验,将70例2型糖尿病合并代谢综合征患者随机分为对照组(口服二甲双胍肠溶片)与治疗组(口服二甲双胍肠溶片及复方番石榴制剂),观察比较治疗12周前后两组患者腹围(WC)、体重指数(BMI)、空腹血糖(FBG)、餐后2h血糖(P2BG)、糖化血红蛋白(HbA1c)、甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)等指标的变化。结果:治疗组可缩小患者WC,减少BMI,降低FBG、P2BG、HbA1c、TG、TC、LDL-C,升高HDL-C,同时可降低HOMA-IR,升高HOMA-β,与服药前比较,差异具有统计学意义(P<0.05);与对照组比较,差异具有统计学意义(P<0.05)。结论:复方番石榴制剂联合二甲双胍可明显缩小患者的WC,减少BMI,降低FBG、P2BG、HbA1c、TG、TC,升高HDL-C,同时可降低HOMA-IR,升高HOMA-β,减轻胰岛素抵抗,保护患者胰岛β细胞功能。
Objective: To observe the effect of compound guava preparations on pancreatic β-cell function in type 2 diabetes mellitus patients with metabolic syndrome. Methods: A randomized controlled clinical trial, 70 patients with type 2 diabetes mellitus and metabolic syndrome were randomly divided into control group (oral metformin enteric-coated tablets) and treatment group (oral metformin enteric-coated tablets and compound guava preparations) After 12 weeks, WC, BMI, FBG, P2BG, HbA1c, TG, TC, LDL-C, HDL-C, FINS, HOMA-IR, HOMA-β and so on. Results: The treatment group can reduce WC, reduce BMI, reduce FBG, P2BG, HbA1c, TG, TC, LDL-C, increase HDL-C, can reduce HOMA-IR, increased HOMA-β, compared with before treatment , The difference was statistically significant (P <0.05); compared with the control group, the difference was statistically significant (P <0.05). Conclusions: Compound guava preparations combined with metformin can significantly reduce WC, reduce BMI, reduce FBG, P2BG, HbA1c, TG, TC, increase HDL-C, while reducing HOMA-IR, increasing HOMA-β, reducing insulin Resistance, protection of pancreatic β-cell function in patients.