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肿瘤细胞蛋氨酸依赖性的增高是一种特异性的代谢缺陷,这种代谢缺陷也是选择性治疗肿瘤的一个靶点。研究发现,蛋氨酸γ-裂解酶(蛋氨酸酶、L-Methionine-γLyase)可以特异地裂解细胞内外的蛋氨酸,从而强烈地抑制肿瘤细胞的生长,并诱发其凋亡,但对正常细胞无影响,从而发挥抗肿瘤的作用。现在还发现,蛋氨酸酶消除体内的蛋氨酸,能够导致基因的甲基化作用和DNA合成发生改变,以增强抗肿瘤效果。动物研究和临床试验表明,蛋氨酸酶可以消除多种依赖蛋氨酸的肿瘤细胞,因此是一种蛋氨酸限制抗癌策略。蛋氨酸酶显示出作为一种新型的基因治疗方法的巨大前景。本文特对此做一综述。
Methionine-dependent increase in tumor cells is a specific metabolic defect, this metabolic defect is also a selective target for the treatment of cancer. The study found that methionine γ-lyase (methionine, γ-Lyase) can specifically cleave intracellular methionine, which strongly inhibited the growth of tumor cells and induce apoptosis, but no effect on normal cells and thus Play antitumor effect. It has also been found that methioninase can eliminate methionine and cause methylation and DNA synthesis to enhance anti-tumor effect. Animal studies and clinical trials have shown that methioninase can eliminate a variety of methionine-dependent tumor cells and is therefore a methionine-restricted anticancer strategy. Methioninase has shown great promise as a novel gene therapy method. This article makes a special review of this.