肾脏疾病的进展不仅与肾小球、间质纤维化有关,也与肾血管的病变有关。肾纤维化过程中,肾脏对肾单位数目减少最初的反应是毛细血管增多引起肾单位代偿肥大[1] ;肾小球及管周毛细血管的微血管内皮细胞损伤直接引起肾血流量减少、肾缺血及纤维化,导致肾脏病恶化;大血管病变包括持 The progress of kidney disease not only with glomerular, interstitial fibrosis, but also with renal vascular disease. During renal fibrosis, the initial response of the kidneys to the reduction of the number of nephrons is that capillary enlargement causes compensatory hypertrophy of the nephrons [1]; injury of the microvascular endothelial cells of the glomerular and peritubular capillaries leads directly to a decrease of renal blood flow, Ischemia and fibrosis, leading to deterioration of kidney disease; macrovascular disease, including support