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肝癌的发生和发展是多种遗传改变的累积造成的，原发性肝细胞癌（ｈｅｐａｔｉｃｃｅｌｌｕｌａｒｃａｒｃｉｎｏｍａ，ＨＣＣ）的发生、发展与癌基因的激活和抑癌基因的失活有关。ＭＴＳ１／ｐ１６是新发现的多重抑癌基因（ｍｕｌｔｉｐｌｅｔｕｍｏｕｒｓｕｐｐｒｅｓｓｏｒ
The occurrence and development of hepatocellular carcinoma is caused by accumulation of multiple genetic alterations. The occurrence and development of hepatocellular carcinoma (HCC) is related to the activation of oncogenes and the inactivation of tumor suppressor genes. MTS1/p16 is a newly discovered multiple tumor suppressor gene (multiple tumors suppressor