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在大鼠肝脏缺血再灌注模型基础上建立稳定的缺血预处理模型,观察其保护作用,结果发现预处理与缺血再灌注组相比血清肝酶(ALT、AST),透明质酸水平及肝组织局部MDA含量均低,而组织ATP含量及能荷值均高,形态学损伤改变轻;同时发现预处理组组织腺苷含量明显高于缺血再灌注组。实验表明缺血预处理能有效减轻肝脏的缺血再灌注损伤,腺苷分子参与了这一保护机制。
To establish a stable model of ischemic preconditioning on the basis of rat liver ischemia-reperfusion model and to observe its protective effect. The results showed that compared with the ischemia-reperfusion group, the levels of serum liver enzymes (ALT, AST), hyaluronic acid And local liver tissue MDA content were low, and tissue ATP content and energy charge values were high, morphological changes were light; also found that pretreatment group adenosine content was significantly higher than ischemia-reperfusion group. Experiments show that ischemic preconditioning can effectively reduce the liver ischemia-reperfusion injury, adenosine molecules involved in this protection mechanism.