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[目的]观察人宫颈癌基因(HCCR)的过度表达对评估乳腺癌患者预后的意义.[方法]选择105例因浸润性导管癌而行手术患者的肿瘤组织标本,采用免疫组织化学染色方法观察标本中HCCR、雌激素受体(ER)及孕酮受体(PR)的表达情况,分析HCCR表达与各组织学等级的关系、与ER,PR的相关性及与患者生存时间和生存率的相关性.[结果]105例乳腺癌患者中HCCR阳性表达率为26.7%.HCCR表达与临床分期、核异型性等级、核分裂、组织学等级及ER,PR表达均无相关关系.尽管呈HCCR的染色范围越广,患者的10年生存率越高的趋势,但无统计学意义.[结论]尚不能确定HCCR是乳腺癌的预后因子.
[Objective] To observe the significance of human cervical cancer gene (HCCR) overexpression in assessing the prognosis of patients with breast cancer. [Methods] Tumor samples from 105 patients with invasive ductal carcinoma who underwent surgery were selected and observed by immunohistochemical staining The expression of HCCR, estrogen receptor (ER) and progesterone receptor (PR) in specimens were analyzed. The relationship between HCCR expression and histological grade was analyzed. The correlation between HCCR expression and ER, PR and the survival time and survival rate [Results] The positive rate of HCCR in 105 cases of breast cancer was 26.7% .The expression of HCCR had no correlation with clinical stage, nuclear atypia level, mitosis, histological grade and ER, PR expression.While HCCR The wider the range of staining, the higher the 10-year survival rate of patients, but no statistical significance. [Conclusion] HCCR is not yet determined the prognostic factor for breast cancer.