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目的探讨姜黄提取物的免疫调节作用。方法 ICR雌性小鼠,经口灌胃给药,剂量分别为0.30、0.60、1.80g/kg·bw,连续30d后,进行细胞免疫实验(迟发型变态反应和ConA诱导的脾淋巴细胞转化实验)、体液免疫实验(抗体生成细胞检测和血清溶血素水平(HC50)测定)、巨噬细胞吞噬能力测定(碳廓清实验和腹腔巨噬细胞吞噬鸡红细胞实验)和NK细胞活性测定。结果姜黄提取物能提高小鼠的血清溶血素水平(0.60、1.80g/kg·bw剂量组HC50与对照组比较分别提高了11.1、18.6)及脾淋巴细胞转化能力(0.30、1.80g/kg·bw剂量组OD差值与对照组比较分别提高了0.104、0.111)。结论姜黄提取物具有增强免疫力作用。
Objective To investigate the immunomodulatory effect of turmeric extract. Methods ICR female mice were orally administrated intragastrically with doses of 0.30, 0.60 and 1.80 g / kg · bw, respectively. After 30 consecutive days, cellular immunity experiments (delayed-type hypersensitivity and ConA-induced splenic lymphocyte transformation) , Humoral immunity test (antibody producing cell assay and serum hemolysin level (HC50) assay), macrophage phagocytosis assay (carbon clearance assay and peritoneal macrophage phagocytosis of chicken erythrocytes), and NK cell activity assays. Results Turmeric extract increased serum hemolysin level in mice (HC50 at 0.60, 1.80 g / kg · bw and control groups increased by 11.1 and 18.6, respectively) and splenic lymphocyte transformation ability (0.30, 1.80 g / kg · OD value of bw dose group increased by 0.104 and 0.111 respectively compared with the control group. Conclusion Turmeric extract can enhance the immune function.