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结节病是一种多器官多系统受累的肉芽肿性疾病,其发病机制尚不明确,免疫功能紊乱参与了结节病的发病过程,并影响着结节病的预后。参与结节病免疫反应的主要是细胞免疫,T细胞起着重要的作用。活化的T细胞产生Th1型细胞因子,使局部炎性反应放大,并形成肉芽肿,同时机体还存在着免疫缺陷,对结核杆菌的免疫反应受到抑制。这种免疫矛盾的现象可能与T细胞亚型的功能及其在结节病患者体内的变化有关。通过对这些T细胞亚型的研究将有助于了解结节病的发病机制及其可能的抗原,并为寻找结节病有效的防治方法开辟新的途径。
Sarcoidosis is a multi-organ multi-system granulomatous disease, its pathogenesis is not clear, immune dysfunction involved in the pathogenesis of sarcoidosis, and affect the prognosis of sarcoidosis. The main immune response involved in sarcoidosis is cellular immunity, T cells play an important role. Activation of T cells produce Th1-type cytokines, the local inflammatory response amplification and the formation of granulomas, while the body still exists immunodeficiency, the immune response to Mycobacterium tuberculosis was inhibited. This phenomenon of immune contradiction may be related to the function of T cell subtypes and their changes in patients with sarcoidosis. Through the study of these T cell subtypes, it will be helpful to understand the pathogenesis of sarcoidosis and its possible antigens, and open up new avenues for the effective prevention and treatment of sarcoidosis.