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用免疫组化ＬＳＡＢ法检测４２例食管鳞癌切除标本癌旁粘膜中ＣＤ４４ｖ４／５的表达。结果发现：癌旁正常上皮、单纯增生上皮、轻度不典型增生上皮、重度不典型增生上皮和原位癌中的阳性表达率分别为１１．１１％（２／１８）、１７．３９％（４／２３）、５６．２５％（９／１６）、５７．１４％（８／１４）和６９．２３％（９／１３），正常上皮、单纯增生上皮和轻、重度不典型增生上皮及原位癌之间差异显著（Ｐ＜０．０１）。结果提示：ＣＤ４４ｖ４／５表达与食管鳞癌的发生发展有关。
The expression of CD44v4/5 in paratumor mucosa of 42 specimens of esophageal squamous cell carcinoma was detected by immunohistochemistry (LSAB). The results showed that the positive expression rates in normal paraneoplastic, simple hyperplastic epithelium, mild dysplasia epithelium, severe dysplasia epithelial and carcinoma in situ were 11.11% (2/18) and 17.39% ( 4/23), 56.25% (9/16), 57.14% (8/14) and 69.23% (9/13), normal epithelium, simple hyperplasia epithelium, and mild to severe dysplasia epithelium There was a significant difference between carcinomas in situ (P<0.01). The results suggest that the expression of CD44v4/5 is related to the occurrence and development of esophageal squamous cell carcinoma.