【摘 要】
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This study showed that abnormal behavioral changes were greatly improved in rats displaying Parkinsons disease-like symptoms after intragastric administration o
【机 构】
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First Department of Neurology,Post-doctoral Research Station
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This study showed that abnormal behavioral changes were greatly improved in rats displaying Parkinsons disease-like symptoms after intragastric administration of Xifeng Dingchan decoction at 15, 7.5, 3.75 g/kg per day. In addition, tyrosine hydroxylase mRNA expression in the substantia nigra of the midbrain was up-regulated, and tyrosine hydroxylase content in the midbrain ventral tegmentum and substantia nigra pars compacta was also increased. The effect of administration of Xifeng Dingchan decoction at 7.5 g/kg per day was similar to that of Madopar at 67.5 mg/kg per day. These results indicate that the therapeutic effect of Xifeng Dingchan decoction on Parkinsons disease is associated with the up-regulated protein and mRNA expression of tyrosine hydroxylase in the midbrain.
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