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本研究针对微波热消融肿瘤治疗过程中温度分布实时监测的核心问题,利用计算机模拟生物组织温度场分布,提出了基于有限元的微波消融温度场仿真方法。分别仿真了微波发射功率、作用时间及生物组织热物性参数对温度场分布的影响。研究结果表明:功率增大25%,毁损区温度平均升高20%;功率增大50%,温度升高40%;功率增大75%,温度升高60%。作用时间延长,温度场分布基本不变,但有效毁损体积增大,时间延长2倍可使毁损体积增大150%。导热系数对热疗远场区热能的扩散产生作用。经验证发现仿真结果与实验结果误差较小,证明了仿真方法的准确性。研究结果对于通过微波消融术前模拟来确定合适的发射功率和作用时间,以及制订合理的手术计划有重要的参考价值。
In this study, the core issue of real-time monitoring of temperature distribution in the treatment of microwave-assisted thermal ablation of tumors was studied. The distribution of temperature distribution in biological tissues was simulated by computer. A temperature field simulation method based on finite element method was proposed. The effects of microwave power, time and biological parameters on temperature distribution were simulated. The results show that the power is increased by 25%, the average temperature in the damaged area is increased by 20%, the power is increased by 50%, the temperature is increased by 40%, the power is increased by 75% and the temperature is increased by 60%. With the extension of time, the distribution of temperature field is basically unchanged, but the volume of effective damage increases. The time of 2 times longer can increase the volume of damage by 150%. Thermal conductivity plays a role in the diffusion of thermal energy in the far field of hyperthermia. It is verified that the error between the simulation result and the experimental result is small, which proves the accuracy of the simulation method. The results provide an important reference value for the determination of appropriate transmit power and duration of action by pre-microwave ablation simulations and for the development of a rational surgical plan.