脂质体用作药物载体已有多年,然而众所周知多层脂质体(MLV)的药物包裹率很低,这是由于用薄膜法制备时,将水溶液加至类脂膜中,穿透干燥类脂膜使磷脂水化,由于脂相和水相间的表面积小,在形成脂质体膜时,水溶液中的药物不能密切与类脂质接触,因此药物包裹率低。逆相蒸发法(REV)克服了包裹率低的问题,在形成膜时增加类脂和水相之间的表面积,它将水滴乳化在有机相中(W/O乳剂),再形成脂质体。在W/O乳剂 Liposomes have been used as drug carriers for many years, however, it is well known that MLVs have a very low rate of drug encapsulation because of the aqueous solution added to the lipid membrane when prepared by the thin film method, Lipid membrane to phospholipid hydration, due to the small surface area between the lipid phase and aqueous phase, the formation of liposome membrane, the drug in aqueous solution can not be in close contact with lipidoid, the drug package rate is low. Reverse Phase Evaporation (REV) overcomes the problem of low package rates by increasing the surface area between the lipid and the aqueous phase upon film formation, emulsifying water droplets in the organic phase (W / O emulsion) and then forming liposomes . The W / O emulsion