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目的 探讨亚砷酸注射液的抗炎与镇痛的药效。方法 采用测定二甲苯致小鼠耳肿胀度 ,测定Freund’s完全佐剂性关节炎大鼠两侧后肢足跖肿胀度 ,大鼠体重及脾脏、胸腺、肾上腺、髂淋巴结的脏器指数的方法 ,观察亚砷酸注射液的抗炎作用 ;采用乙酸致小鼠扭体反应 ,观察亚砷酸注射液的镇痛效果。结果 亚砷酸注射液对二甲苯诱发的小鼠耳急性炎性耳肿胀有显著抑制作用 ;治疗性给予亚砷酸注射液 (4mg kg)第 5、8天 ,对佐剂关节炎注射侧足肿胀及另一侧后肢免疫炎性或迟发性超敏反应引起的足肿胀均有显著的抑制作用 ;关节炎评分显示 ,亚砷酸注射液对佐剂关节炎损害具有显著的保护作用 ;亚砷酸注射液对乙酸诱发小鼠疼痛性扭体反应也有显著的抑制作用。结论 亚砷酸注射液具有抗炎与镇痛效用。
Objective To investigate the anti-inflammatory and analgesic effects of arsenite injection. Methods The method of xylene-induced ear swelling was used to measure the degree of swelling of the hind limbs on both sides of Freund’s adjuvant arthritis rats, the body weight of the rats and the organ index of spleen, thymus, adrenal and iliac lymph nodes Anti-inflammatory effect of arsenite injection; acetic acid induced writhing reaction in mice to observe the analgesic effect of arsenious acid injection. Results Arsenite injection had a significant inhibitory effect on xylene-induced acute inflammatory ear swelling in mice. Arsenic trioxide injection (4 mg kg) was given on the 5th and 8th day after treatment with adjuvant arthritis Swelling and the other side of the hind limb immune inflammation or delayed hypersensitivity induced foot swelling were significantly inhibited; arthritis score showed that arsenic acid injection adjuvant arthritis damage has a significant protective effect; Arsenic acid injection on acetic acid induced pain writhing reaction was also significantly inhibited. Conclusion Arsenite injection has anti-inflammatory and analgesic effects.