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目的观察运用家庭长期氧疗(LTOT)的方式治疗慢性阻塞性肺疾病(COPD)的临床疗效。方法选取我院2009年1月-2012年4月收治的96例COPD患者,随机将其分为氧疗组和对照组各48例,氧疗组给予固定时间供氧治疗,每日供氧持续时间大于15h,供氧种类为压缩氧,方式为鼻导管供氧,供氧流量为2L/min,两组观察周期均为1年,并持续随访1年,随访期限为2个月/次,观察指标选择患者治疗前后肺功能及血气分析。结果经过LTOT,重症COPD患者的肺活量(VC)、用力肺活量(FVC)、1秒钟用力呼气容积(FEV1)均有明显改善,氧疗组经长期治疗后动脉血氧浓度明显高于治疗前,也高于对照组的相应指标,氧疗组动脉血二氧化碳分压明显低于对照组,差异具有显著性。结论慢性阻塞性肺病患者通过合理长期氧疗可以明显提高患者动脉血内氧气浓度和降低动脉血内二氧化碳浓度,增加组织供氧,缓解呼吸困难症状,降低肺动脉压力,提高生活舒适度。
Objective To observe the clinical efficacy of long-term home oxygen therapy (LTOT) in the treatment of chronic obstructive pulmonary disease (COPD). Methods A total of 96 patients with COPD who were admitted to our hospital from January 2009 to April 2012 were randomly divided into two groups: oxygen therapy group (48 cases) and control group (48 cases). Oxygen therapy group received fixed oxygen therapy and daily oxygen supply Time is greater than 15h, oxygen supply for the compressed oxygen, the way for the nasal catheter oxygen supply oxygen flow of 2L / min, the observation period of both groups were 1 year and follow-up of 1 year follow-up period of 2 months / time, Observe the index of patients before and after treatment of lung function and blood gas analysis. Results After LTOT, vital capacity (VC), forced vital capacity (FVC) and forced expiratory volume per 1 second (FEV1) were significantly improved in patients with severe COPD. The arterial oxygen concentration in oxygen therapy group after long-term treatment was significantly higher than that before treatment , Also higher than the corresponding indicators of the control group, oxygen therapy group arterial partial pressure of carbon dioxide was significantly lower than the control group, the difference was significant. Conclusions Chronic obstructive pulmonary disease in patients with long-term oxygen therapy can significantly improve arterial blood oxygen concentration and reduce arterial blood carbon dioxide levels, increase tissue oxygen supply, alleviate the symptoms of dyspnea, reduce pulmonary artery pressure, and improve life comfort.