论文部分内容阅读
视网膜细胞发育障碍和眼部血管的病理性生长可见于多种眼部疾病,严重影响患者视力.Hedgehog信号转导通路已被证实参与视网膜神经节细胞、无长突细胞、视锥细胞、视杆细胞、Müller胶质细胞、视网膜色素上皮(RPE)细胞等细胞生长发育的多个过程.近年来研究表明,Hedgehog信号通路可以调控视网膜细胞的分化和发育,并在眼部新生血管生成中起到关键性作用.本文从Hedgehog信号通路的组成、Hedgehog信号通路与视网膜细胞发育、视网膜再生、Hedgehog信号通路与眼部病理性血管生成4个方面就Hedgehog信号通路在视网膜细胞发育及病理性血管生成中的作用进行综述,以期为视网膜及眼部血管性疾病的治疗提供新的靶点.“,”The pathological growth of retinal cells and ocular pathologic angiogenesis can be seen in a variety of eye diseases,which seriously affect the visual acuity of patients.The Hedgehog signal pathway has been demonstrated to be involved in the development of retinal ganglion cells,amacrine cells,cone cells and rod cells,Müller glial cells and retinal pigment epithelial cells.This paper discusses the function of Hedgehog signal pathway in the development of retinal cells and ocular pathologic angiogenesis,which may provide a new therapeutic target for retinal and ocular vascular diseases.