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目的探讨神经元特异性烯醇化酶(NSE)在热性惊厥(FC)患儿的变化及其临床意义。方法 200例热性惊厥患儿,其中单纯热性惊厥患儿100例作为单纯组,复杂性热性惊厥患儿100例作为复杂组;同期100例上呼吸道感染患儿作为对照组。比较三组神经元特异性烯醇化酶水平。结果复杂组患儿的神经元特异性烯醇化酶水平(22.52±3.65)μg/L明显高于单纯组(11.58±2.69)μg/L和对照组(7.52±0.18)μg/L(P<0.05);单纯组神经元特异性烯醇化酶水平明显高于对照组(P<0.05)。结论热性惊厥患儿的神经元特异性烯醇化酶水平会明显提升,复杂性热性惊厥患儿的神经元特异性烯醇化酶水平更高,可将其作为诊断指标。
Objective To investigate the changes and clinical significance of neuron-specific enolase (NSE) in children with febrile seizures (FC). Methods 100 cases of children with febrile seizures, 100 cases of simple febrile seizures in children as simple group, 100 cases of complex febrile seizures as a complex group; 100 cases of children with upper respiratory tract infection over the same period as a control group. Three groups of neuron-specific enolase levels were compared. Results The level of neuron-specific enolase (22.52 ± 3.65) μg / L was significantly higher in the complicated group than in the simple group (11.58 ± 2.69) μg / L and the control group (7.52 ± 0.18) μg / L ). The level of neuron-specific enolase in the simple group was significantly higher than that in the control group (P <0.05). Conclusions The level of neuron-specific enolase in children with febrile seizures will be significantly increased, and children with complicated febrile seizures have higher levels of neuron-specific enolase, which may be used as a diagnostic indicator.