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1973年有人报告急性粒细胞白血病(AML)患者的染色体为正常核型(NN)或正常和异常有丝分裂混合型(AN)者的预后优于只有异常核分裂型(AA)者。随后又有人报告染色体复合异常者预后差,倒位者预后好,而为三倍体8者则介于二者之间。为了进一步研究AML患者的染色体异常与预后的关系,作者于1981-1986年间采用细胞分裂中期技术对139例初发的AML的骨髓和/或外周血细胞进行染色体观察,并对其中112例采用联合化疗的患者分析了染色体异常与预后的关系。本组患者在进展为AML前均无骨髓增生异常综合征病史,以及因原发恶性肿瘤而接受化疗或放疗的病史。作者发现:染色体的总畸变率
In 1973, it was reported that the prognosis of patients with acute myeloid leukemia (AML) who had normal chromosome (NN) or normal and abnormal mitotic mixture (AN) was superior to those with only aberrant mitosid (AA). Then there were reports of chromosomal abnormalities were poor prognosis, the prognosis is good, and the triploid 8 is in between the two. To further investigate the relationship between chromosomal abnormalities and prognosis in patients with AML, the authors used chromosomal observations of 139 cases of newly diagnosed AML bone marrow and / or peripheral blood cells using metaphase during 1981-1986, and 112 of them were treated with combination chemotherapy Of patients analyzed the relationship between chromosomal abnormalities and prognosis. This group of patients had no history of myelodysplastic syndrome before progression to AML and a history of chemotherapy or radiotherapy due to primary malignancy. The authors found: The total chromosome aberration rate