论文部分内容阅读
主要尿蛋白(MUPs)属于脂质运载蛋白家族,具有保守的中心疏水β链桶状特征性结构域,具有调节种属内与种属间个体间化学信息交流的功能.MUPs主要在肝合成并分泌入血,作为载体与信息素等亲脂性小分子结合,延长其半衰期,一并从肾过滤排泄入尿液,延缓尿迹中信息素的挥发,从而延长信息素的作用时间.啮齿类动物的MUPs本身具有高度多态性,能够发挥类似信息素的作用直接编码个体信息,调节种属内的生物活动.此外,MUPs还能够发挥利它素的功能引起其它种属的畏惧反应.新近研究发现,MUPs受到机体营养状态的调节,与代谢性疾病及糖脂代谢密切相关,但机制尚不清楚.MUPs的功能和机制探索对于化学信息交流与糖脂代谢研究具有重要意义.本文旨在对MUPs的最新研究结果展开简要综述及讨论.
Major urinary proteins (MUPs), which belong to the lipocalin family and have a conserved central hydrophobic β-chain barrel-like characteristic domain, have the function of regulating chemical information exchange between individuals within and among species. Secreted into the blood, as a carrier and pheromone and other lipophilic small molecules combined to extend its half-life, together with urine excretion through the urine excreted into the urine, delay the volatilization of pheromones in the urine, thereby prolonging the role of pheromones. MUPs are highly polymorphic in their own right and can act like pheromones to directly encode individual information and regulate biological activities within species. In addition, MUPs can also function as ritosin to cause fear reactions from other species. Found that MUPs are regulated by the nutritional status of the body and closely related to metabolic diseases and glucose and lipid metabolism, but the mechanism is not clear.MUPs functional and mechanism exploration is of great significance for the study of chemical information exchange and glucose and lipid metabolism.This paper aims to A summary and discussion of the latest MUPs findings.